生物医学工程
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宓现强
研究员、兼职博导
宓现强,中国科学院上海微系统与信息技术研究所研究员,博士生导师,Bio-X课题组长。国家重点研发计划项目首席科学家。在复旦大学取得博士学位,曾在中科院上海高等研究院从事生物医学传感技术研究,具有丰富的生物与信息技术交叉研究经验。于2019年6月加入中国科学院上海微系统与信息技术研究所。
宓现强长期从事生命健康领域的智慧感知与调控技术研究工作,主要研究方向为生物微流控检测及器官芯片研究,基于SQUID的生物磁检测与成像研究等。主持/承担了国家重点研究计划项目、中科院STS项目、上海市生物医药重点项目等20多项重大科研项目/任务,取得多项国内外领先的成果,在生物传感器、微流控芯片、物理光电探测等领域取得多项创新性成果。在Proceedings of the National Academy of Sciences、Biosensors and Bioelectronics等知名期刊发表论文120余篇,申请专利32件(获授权20余件)。多次受邀参加国际学术会议并作邀请报告,担任多家知名学术期刊编委,在多个国家及国际学术组织任职。2020年入选上海市优秀学术带头人项目。
联系地址:上海市浦东新区张江高科技园区海科路100号
个人主页:https://people.ucas.ac.cn/~mixq#%20268552
主要研究方向、学术成就及创新点:
生命系统网络分析、纳米生物编码探针,微流控生物检测及器官芯片,液滴软物质,量子探测及成像
学术论文及著作:
1 Cubic DNA nanocage-based three-dimensional molecular beacon for accurate detection of exosomal miRNAs in confined spaces Biosensors and Bioelectronics. 2022, 204:114077
2 Tetrahedral DNA Framework-Programmed Electrochemical Biosenors with Gold Nanoparticles for Ultrasensitive Cell-Free DNA Detection.Nanomaterials 2022, 12, 666
3DNA-based functionalization of two-dimensional MoS2 FET biosensor for ultrasensitive detection of PSA.Applied Surface Science. 548 (2021) 149169
4 Electrochemical DNA Sensor for Sensitive brca1 Detection Based on DNA Tetrahedral-Structured Probe and Poly-Adenine Mediated Gold Nanoparticles. Biosensors 2020, 10, 78
5 DNA tetrahedron mediated immune sandwich assay for rapid, sensitive, and automatic detection of PSA through microfluidic electrochemical detection system. Microsystems and nanoengineering,2021 (2021)7:33
6 A DNA Tetrahedral Structure-Mediated Ultrasensitive Fluorescent Microarray Platform for Nucleic Acids Tests. Sensors and Actuator B : Chemical,2020,321: 128538
7 Framework Nucleic Acid-Enabled Programming of Electrochemical Catalytic Properties of Artificial Enzymes.ACS Appl. Mater.Interfaces. 2019,11(24):21859-21864
8 Poly-adenine-mediated Spherical Nucleic Acids for Strand Displacement-based DNA/RNA Detection. Biosensors and Bioelectronics. 2019,127:85–91
9 Fluorescent biosensors enabled by graphene and graphene oxide.Biosensors and Bioelectronics 2017;89(Pt 1):96-106
10 DNA Tetrahedral Nanostructure-Based Electrochemical miRNA Biosensor for Simultaneous Detection of Multiple miRNAs in Pancreatic Carcinoma.ACS Appl Mater Interfaces. 2017, 9(28):24118-24125