个人简介：林海双，男，中国科学技术大学苏州高等研究院特任副研究员，主要从事1) 利用微流控-水凝胶技术进行人多潜能干细胞(hESC和iPSC)的扩增，分化和重编程，组织工程及临床转化研究；2) 利用基因密码子扩展等基因编辑技术对蛋白的定点修饰，调控干细胞/类器官发育分化，减毒活疫苗研发，抗耐药流感病毒新策略研发，及无义突变疾病治疗研究。目前共发表SCI论文35篇，其中以第一/共一作者在Theranostics，Biomaterials, Advanced Healthcare Materials，ACS Applied Materials & Interfaces, Biofabrication, Cell Death & Differentiation, Stem Cell Reports, Biomaterials Science, Vaccines等杂志公开发表SCI论文18篇；谷歌学术总引用1256次，单篇最高引用164次，H-index 为21。担任American Journal of Biomedical and Life Sciences, Scientific Reports等期刊审稿人，及JoVE杂志的Invited Guest editor。

电子邮箱：hlin9@ustc.edu.cn

联系地址：苏州工业园区独墅湖科教创新区仁爱路166号

工作经历：

2023.11-至今，       中国科学技术大学苏州高等研究院，特任副研究员

2019.08-2022.08， 北京大学，助理研究员

2015.01-2018.12， University of Nebraska-Lincoln (USA), Postdoc

学习经历：

2011.09-2014.07，北京协和医学院，生物化学与分子生物学 博士

2008.09-2011.07，大连医科大学，生物化学与分子生物学 硕士

2004.09-2008.07，华北煤炭医学院，生物技术 学士

主要研究方向、学术成就及创新点：

干细胞工程/组织工程/类器官工程及再生医学研究

基因编辑调控干细胞/类器官发育分化

重要科研获奖情况：

若干微小RNA 和蛋白基因在髓系生产和白血病中的功能和机制研究，教育部高等学校自然科学奖二等奖，2018

学术论文及著作

1. Xiaodong Zhang†, Haishuang Lin†✉, Liangzhen Dong†, Qing Xia✉. Recapitulating Influenza Virus Infection and Facilitating Antiviral and Neuroprotective Screening in Tractable Brain Organoids. Theranostics. 2022 Jul 7;12(12):5317-5329. (IF: 11.6，SCI-1区).

2. Haishuang Lin, Qiang Li, Qian Du, Ou Wang, Zhanqi Wang, Leonard Akert, Mark A. Carlson, Chi Zhang, Anuradha Subramanian, Chi Zhang, Matthew Lunning, Ming Li, Yuguo Lei✉. Integrated generation of induced pluripotent stem cells in a low-cost device. Biomaterials. 2019 Jan;189: 23-36. (IF: 15.304, SCI-1区) .

3. Haishuang Lin*, Qian Du*, Qiang Li, Ou Wang, Zhanqi Wang, Neety Sahu, Christian Elowsky, Kan Liu, Chi Zhang, Soonkyu Chung, Bin Duan, Yuguo Lei✉. Hydrogel-based bioprocess for scalable manufacturing of human pluripotent stem cells-derived neural stem cells. ACS Applied Materials & Interfaces. 2018 Sep 5;10(35):29238-29250. (IF: 10.383, SCI-1区).

4. Haishuang Lin*, Qiang Li*, Ou wang, Jack Rauch, Braden Harm, Hendrik J. Viljoen, Chi Zhang, Erika Van Wyk, Chi Zhang, Yuguo Lei✉. Automated Expansion of Primary Human T Cells in Scalable and Cell-Friendly Hydrogel Microtubes for Adoptive Immunotherapy. Advanced Healthcare Materials. 2018 Aug;7(15): e1701297. (IF: 11.092, SCI-1区).

5. Haishuang Lin*, Qiang Li*, Yuguo Lei✉, Three-dimensional tissues using human pluripotent stem cell spheroids as biofabrication building blocks. Biofabrication. 2017 Apr 24;9(2):025007. (Highlights of 2017. IF: 11.061, SCI-1区).

6. Jia-Nan Gong*, Jia Yu*, Hai-Shuang Lin*, Xin-Hua Zhang, Xiao-Lin Yin, Zhen Xiao, Fang Wang, Xiao-Shuang Wang, Rui Su, Chao Shen, Hua-Lu Zhao, Yan-Ni Ma, Jun-Wu Zhang✉. The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia. Cell Death and Differentiation. 2014 Jan;21(1):100-112. (IF: 12.067, SCI-1区).

7. Ningning Shi#, Le Tong#, Haishuang Lin#✉, Zhetao Zheng, Haoran Zhang, Liangzhen Dong, Yuelin Yang, Yuxuan Shen, Qing Xia✉. Optimizing eRF1 to enable the genetic encoding of three distinct Non-canonical amino acids in mammalian cells. Advanced Biology (Weinh). 2022 Jul 11; e2200092. (IF: 4.053, SCI-1区).

8. Zhujun Jiang†, Haishuang Lin†, Haoran Zhang†, Ningning Shi†, Zhetao Zheng, Liangzhen Dong, Yuelin Yang, Qing Xia✉. An Integrative Analysis of the Immune features of Inactivated SARS-CoV-2 Vaccine (CoronaVac). Vaccines. 2022 May 30;10(6):878. (IF: 4.961, SCI-2区).

9. Xuesheng Wu†, Zhetao Zheng†, Hongmin Chen†, Haishuang Lin†, Yuelin Yang, Yachao Bai, Qing Xia✉. Sterilization of drug-resistant influenza virus through genetic interference inspired by unnatural amino acid-engineered particles. Advanced Therapeutics. 2022. 5,2200069. (Cover article， IF: 5.003, SCI-1区).

10. Qing Liu*, Zhen Liu*, Hongyu Gu*, Yuxia Ge*, Xusheng Wu*, Fuxing Zuo*, Qian Du, Yuguo Lei✉, Zhanqi Wang✉, Haishuang Lin✉. Comparative Study of Differentiating Human Pluripotent Stem Cells into Vascular Smooth Muscle Cells in Hydrogel-based Culture Methods. Regenerative Therapy, 2022 Dec 21;22:39-49.（IF:3.651）

11. Zhanqi Wang*, Fuxing Zuo*, Qing Liu*, Xusheng Wu*, Qian Du, Yuguo Lei✉, Zhangmin Wu✉, Haishuang Lin✉. Comparative Study of Human Pluripotent Stem Cell-Derived Endothelial Cells in Hydrogel-Based Culture Systems. ACS Omega. 2021 Mar 2;6(10):6942-6952. (IF: 4.132，SCI-3区)

12. Haishuang Lin, Qian Du, Qiang Li, Ou Wang, Zhanqi Wang, Christian Elowsky, Kan Liu, Chi Zhang, Soonkyu Chung, Bin Duan, Yuguo Lei✉. Manufacturing Human Pluripotent Stem Cells Derived Endothelial Cells in Scalable and Cell-friendly Microenvironments. Biomaterials Science. 2018 Dec 18;7(1):373-388. (IF: 7.59, SCI-2区)

13. Haishuang Lin*, Xuefeng Qiu*, Qian Du, Qiang Li, Ou Wang, Leonard Akert, Zhanqi Wang, Dirk Anderson, Kan Liu, Linxia Gu, Chi Zhang, Yuguo Lei✉. Engineered Microenvironment for Manufacturing Human Pluripotent Stem Cells Derived Vascular Smooth Muscle Cells. Stem Cell Reports. 2019 Jan 8;12(1):84-97. (IF: 7.294, SCI-1区).

14. Haishuang Lin, Qian Du, Qiang Li, Ou Wang, Zhanqi Wang, Kan Liu, Chi Zhang, Soonkyu Chung, Bin Duan, Yuguo Lei✉. Differentiating human pluripotent stem cells into vascular smooth muscle cells in three dimensional thermoreversible hydrogel. Biomaterials Science. 2018 Dec 18;7(1):347-361. (IF: 7.59, SCI-2区)

15. Haishuang Lin, Qian Du, Qiang Li, Ou Wang, Christian Elowsky, Kan Liu, Chi Zhang, Soonkyu Chung, Bin Duan, Yuguo Lei✉. A Scalable and Efficient Bioprocess for Manufacturing Human Pluripotent Stem Cells-Derived Endothelial Cells. Stem Cell Reports. 2018 Aug 14;11(2):454-469. (IF: 7.294, SCI-1区)

16. Haishuang Lin, Qiang Li, Yuguo Lei✉. An Integrated Miniature Bioprocessing for Personalized Human Induced Pluripotent Stem Cell Expansion and Differentiation into Neural Stem Cells. Scientific Reports. 2017 Jan 6; 7:40191. (IF: 4.996, SCI-3区)

17. Qiang Li*, Haishuang Lin*, Ou Wang, Xuefeng Qiu, Srivatsan Kidambi, Loic P. Deleyrolle, Brent A. Reynolds, Yuguo Lei✉. Scalable Production of Glioblastoma Tumor initiating Cells in 3 Dimension Thermoreversible Hydrogels. Scientific Reports. 2016 Aug 23; 6:31915. (IF: 4.996, SCI-3区)

18. Hai-Shuang Lin, Jia-Nan Gong, Rui Su, Ming-Tai Chen, Li Song, Chao-Shen, Fang Wang, Yan-Ni Ma, Hua-Lu Zhao, Jia Yu, Wei-Wei Li, Li-Xia Huang, Xin-Hua Xu, Jun-Wu Zhang✉. miR-199a-5p inhibits monocyte/macrophage differentiation by targeting the activin A type 1B receptor gene and finally reducing C/EBP alpha expression. Journal of Leukocyte Biology. 2014 Dec; 96 (6):1023-1035. (IF: 6.011, SCI-2区)