王亚清，中国科学技术大学苏州高等研究院特任副研究员，主要从事类器官芯片及生物医学应用研究，包括利用器官芯片技术构建人干细胞衍生脑、肝等类器官3D模型新体系，并用于器官发育研究、疾病模拟和药物评价等。目前发表论文共30篇，其中以第一/共一作者在Advanced Science，Lab on a chip, Life Medicine，Advanced Materials, Accounts of Chemical Research 等国际期刊发表论文14篇；申请发明专利7项，授权专利4项；担任Lab on a chip等期刊审稿人。

电子邮箱： wangyaqing@ustc.edu.cn

工作经历：

2023.03-至今，中科大苏州高等研究院，特任副研究员

2021.04-2023.03，中科院大连化学物理研究所 博士后，中科院特别研究助理

学习经历：

2015.09-2020.12，大连理工大学/中科院大连化学物理研究所，分析化学 博士学位

2012.09-2015.07，北京大学医学部，细胞生物学 硕士学位

2008.09-2012.07，哈尔滨工业大学，生物工程 学士学位

主要学术论文：

1. Y.Q. Wang, P. Wang, J.H. Qin. Human organoids and organs-on-chips for addressing COVID-19 challenges. Advanced Science, 2022, 9: e2105187

2. Y.Q. Wang, J.H. Qin. Advances in human organoids-on-chips in biomedical research. Life medicine, 2022, DOI: 10.1093/lifemedi/lnad007.

3. Y.Q. Wang, P. Wang, J.H. Qin. Microfluidic Organs-on-a-Chip for Modeling Human Infectious Diseases. Accounts of Chemical Research, 2021, 54, 3550−3562.

4. M. Zhang#, P. Wang#, R.H. Luo#, Y.Q. Wang #, Z.Y. Li, Y.Q. Guo, Y.L. Yao, M.H. Li, T.T. Tao, W.W. Chen, J.B. Han, H.T. Liu, K.L. Cui, X. Zhang, Y.T. Zheng, J.H. Qin. Biomimetic human disease model of SARS-CoV-2 induced lung injury and immune responses at organ level. Advanced Science, 2021, 8: 2002928. 

5. Y.Q. Wang #, H.T. Liu#, M. Zhang, H. Wang, W.W. Chen, J.H. Qin. One-step synthesis of composite hydrogel capsules to support liver organoids generation from hiPSCs. Biomaterials science. 2020, 8: 5476-5488.

6. Y.Q. Wang #, H. Wang#, P.W. Deng#, T.T. Tao, H.T. Liu, S. Wu, W.W. Chen, J.H. Qin. Modeling Human Nonalcoholic Fatty Liver Disease (NAFLD) with an Organoids-on-a-chip System. ACS Biomaterials Science & Engineering. 2020, 6: 5734-5743.

7. H.T. Liu#, Y.Q. Wang #, H. Wang, M.Q. Zhao, T.T. Tao, X. Zhang, J.H. Qin. A Droplet Microfluidic System to Fabricate Hybrid Capsules Enabling Stem Cell Organoid Engineering. Advanced Science, 2020, 1903739.

8. K.L. Cui#, Y.Q. Wang #, Y.J. Zhu#, T.T. Tao, F.C. Yin, Y.Q. Guo, H.T. Liu, F. Li, P. Wang, Y.J. Chen, J.H. Qin. Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model. Microsystems & Nanoengineering, 2020, doi.org/10.1038/s41378-020-0165-z.

9. Y.Q. Guo#, R.H. Luo#, Y.Q. Wang #, P.W. Deng#, T.Z. Song#, M. Zhang, P. Wang, X. Zhang, K.L. Cui, T.T. Tao, Z.Y. Li, W.W. Chen, Y.T. Zheng, J.H. Qin. SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip. Science Bulletin, 2020, doi: 10.1016/j.scib.2020.11.015.

10. H.T. Liu#, Y.Q. Wang #, K.L. Cui, Y.Q. Guo, X. Zhang, J.H. Qin. Advances in Hydrogels in Organoids and Organs-on-a-Chip. Advanced Materials, 2019, 1902042.

11. Y.Q. Wang, L. Wang, Y.J. Zhu, J.H. Qin. Human brain organoid-on-a-chip to model prenatal nicotine exposure. Lab on a Chip, 2018,18:851-860.

12. Y.Q. Wang, H. Wang, P.W. Deng, W.W. Chen, Y.Q. Guo, T.T. Tao, J.H. Qin. In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system. Lab on a Chip, 2018,18:3606-3616.

13. Y.Q. Wang, L. Wang, Y.Q. Guo, Y.J. Zhu, J.H. Qin. Engineering stem cell-derived 3D brain organoids in a perfusable organ-on-a-chip system. RSC Advances, 2018, 8: 1677-1685.

14. Y.Q. Wang, W.T. Su, L. Wang, L. Jiang, Y. Liu, L.J. Hui, J.H. Qin. Paper supported long-term 3D liver co-culture model for the assessment of hepatotoxic drugs. Toxicology Research, 2018, 7, 13-21. 

发明专利：

1. 秦建华，王亚清，王丽。一种基于定性滤纸的三维肝模型的药物肝毒性评价方法，专利号：ZL2016 1 1063241.6

2. 秦建华，王亚清，王丽。一种基于微流控芯片的三维类脑发育模型的构建方法，专利号：ZL2017 1 0448568.3

3. 秦建华，王亚清。一种妊娠期尼古丁暴露对胎儿脑损伤的体外模型构建方法，专利号：ZL2017 1 0447086.6

4. 秦建华，刘慧，王亚清，于跃。基于微流控技术的复合空腔微纤维的制备方法，专利号：ZL2016 1 1104451.5

5. 秦建华，王亚清，刘海涛。一种基于双水相液滴微流控的3D类器官工程化方法， CN 201911189616.7

6. 秦建华，王亚清，王慧。一种基于三维类肝芯片的非酒精性脂肪肝体外模型建立方法，CN 202010453269.0

7. 秦建华，王亚清。一种基于器官芯片的人源胎盘组织模型及建立方法，CN 202211591895.1